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eBook details

• Title: Mechanisms of Allergic Inflammation/Allerjik Inflamasyonun Mekanizmalari (Report)
• Author : The Journal of Current Pediatrics
• Release Date : January 01, 2009
• Genre: Health & Fitness,Books,Health, Mind & Body,
• Pages : * pages
• Size : 211 KB

Description

Introduction T cells constitute a large population of cellular infiltrate in atopic/allergic inflammation and a dysregulated immune response appears to be an important pathogenetic factor. Cardinal events during allergic inflammation can be classified as activation, organ selective homing, survival and reactivation and effector functions of immune system cells (1). T cells are activated by aeroallergens, food antigens, autoantigens and bacterial superantigens in allergic inflammation. They are under the influence of skin, lung or nose-related chemokine network and they show organ-selective homing. A prolonged survival of the inflammatory cells in the tissues and consequent reactivation is observed in the subepithelial tissues (2-4). Finally, T cells display effectorfunctions, which result in the induction of hyper IgE, eosinophil survival and mucus hyper production (3-5); and interact with bronchi al epithelial cells and keratinocytes causing their activation and apoptosis (6,7).

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